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HomeEncyclopediaLinaclotide

Linaclotide

Guanylate cyclase-C agonist

Prescription medicine

What it is

A peptide that acts in the gut, used for constipation-predominant IBS and chronic constipation.

What the evidence shows

Supported by clinical trials for its approved gastrointestinal indications.

Safety & reported risks

Prescriber-managed; the most common side effect is diarrhoea.

Status in Australia

A registered prescription medicine for defined gastrointestinal indications.

How it’s lawfully accessed

Prescription-only for an approved indication.

Related peptides

OxytocinEndogenous peptide hormonePrescription medicine

Sources & further reading

This entry is general information about Linaclotide, not a recommendation to use it. We don’t provide dosing, protocols or sourcing. Speak to a registered practitioner.

Written by The Peptides.au editorial team
Editorial review Checked against current TGA, ARTG and AHPRA public guidance
Last updated 1 June 2026

This is general education, not medical advice. Peptides.au does not sell, supply, recommend or promote any product or clinic. Always speak with a registered Australian health practitioner before making any health decision.